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This response is characterised by upregulation of several cytoprotective and detoxification genes, including ferritin, GSH- S -reductase (GSR), GST, GCLM, and GCLC, phase-I drug oxidation enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), MRP, and heme oxygenase-1 (HO-1) [78, 79]

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Editor information Editors and Affiliations Rights and permissions Copyright information 2008 Humana Press, a part of Springer Science + Business Media, LLC About this chapter Cite this chapter Mara, L., Oates, P.J

A motivated athlete or executive gets a mildly raised GGT result, looks up high GGT, and lands in content written for someone with obvious liver disease or heavy alcohol use

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doi: 10.1016/j.celrep.2018.01.075 120 ShockLSThakkarPVPetersonEJMoranRGTaylorSM