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therefore, additional studies are required to explore how changes in exposure influence their effectiveness.166 Moreover, this implies that tirzepatide more strongly affects the absorption of oral contraceptives and that this increased impact may be driven by rapid dose escalation.161 Unlike other pharmacodynamic effects, such as lowering blood glucose or reducing appetite, the delay in gastric emptying shows tachyphylaxis, with the effect gradually decreasing over time.169 Therefore, the investigators have suggested switching to a non-oral contraceptive option or adding a barrier method of contraception for 4 weeks after tirzepatide administration is initiated or if the dose is substantially increased.50,51 DDIs with Narrow Therapeutic Index Drugs Other clinical studies on DDIs have investigated the delayed gastric emptying effect of GLP-1 RA on the pharmacokinetics of drugs with narrow therapeutic index (Table 5)

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Food and Drug Administration (FDA)

doi:10.3389/fendo.2023.1215356

27 The results were similar when semaglutide was compared to insulin glargine and dulaglutide, but importantly, fewer hypoglycaemic episodes were recorded with semaglutide