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Nicotine pouches may potentially be a reduced risk alternative for cigarette smokers or users of other oral tobacco products

In 2012, the gap between male and female cigarette smoking ranged from -5.7 percentage points in Menominee County, WI, to 16.5 percentage points in Sunflower County, MS

Nicotine has been shown to increase the release of interleukin-6 by cultured murine osteoblasts

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Specifically, a single SD increase in creatinine showed a negative association of 22.6% in former smokers (HR: 0.774, 95% CI: 0.6200.967, p -value = 0.0239) and 17.7% in ever-smokers (HR: 0.823, 95% CI: 0.7160.945, p -value = 0.0057)