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Acute and short-to-medium-term exposures were mainly studied by cell/ in vitro and animal studies 18,22,25-29,31,33-37,39-52 , while a single longitudinal study 20 examined long-term exposure

2.Endothelial Dysfunction The vascular endothelium produces important vasodilators with anti-atherosclerotic and anti-aggregatory effects, such as NO and prostacyclin, and thus is a highly dynamic organ possessing anti-inflammatory, antithrombotic, and vasodilatory properties

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95% CI: -0.54 -0.20), whereas secondhand smoke exposure was independently associated with poorer GPH (-0.36%