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This fact contributes to the reason why not all in vitro observations are likely to translate directly into in vivo contexts

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PMID: 19835595 42

As soon as all the weight of the moment shifts to the shoulders of some one manhes the one who vanishes, like a pillar slashed off

[27] They recovered (helped by vomiting), but an ingestion apparently of about 10,000 mg was fatal, as was an injection

I mean, thats a ridiculous example, but people are going to do that in some fashion or another, up to the point where they can convince themselves that theyre still moving forward, even if theyre not