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55 Variants associated with nicotine dependence in the 5 / 3 / 4 gene region (chromosome 15, 15q25) also have a significant association with the number of cigarettes smoked per day, plasma levels of cotinine (a biomarker of nicotine intake), urine levels of tobacco-smoke carcinogens, and the risks of smoking-related diseases

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As Trevino said of Green in a 1998 interview, Hes got a wedge and hes got a putter, but the biggest thing hes got is guts. That quality would prove crucial when, at a routine dental cleaning in April 2003, Green was diagnosed with Stage 4 cancer on his tongue and tonsil

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Rarely, oral cancers can be caused by the human papillomavirus (HPV), but HPV is the most common cause of tonsil cancer or cancer on the back of the tongue