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The Cochrane Risk of Bias (RoB 2) tool for randomized trials 9 was employed to assess bias across multiple domains in two RCTs

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As smokers attempt to quit, they turn to other products believing they are safer

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Estrogen provokes the depressant effect of chronic nicotine on vagally mediated reflex chronotropism in female rats
Smoke is dense, hot, and often harsh, while vapor is lighter, less irritating, and produces a gentler sensation upon inhalation
