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Berkeley: University of California Press

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Symptoms include Vomiting Incoordination Abnormal heart rate Abnormal respiratory rate Uncontrolled urination Uncontrolled defecation Overstimulation Agitation Hyperexcitability Tremors Seizures Paralysis Collapse Coma Death Some dogs react to tobacco poisoning by first becoming hyperexcitable and then become depressed

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For the three main tobacco products of the time - snuff, cigars, and smoking tobacco - manufacturing was primarily done by hand until after the Civil War

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Madjid M, Awan I, Willerson JT, Casscells SW