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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Cantrell J., Kreslake J.M., Ganz O., Pearson J.L., Vallone D., Anesettti-Rothermel A., Xiao H., Kirchner T.R

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"As the nicotine wears off over the course of the night, it can cause a withdrawal effect that may lead to lighter sleep and frequent awakenings," she warns

this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes