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Figure 1 2.1 The role of p53 in spermatogonia The maintenance of spermatogenesis throughout the males lifetime relies on SSCs, which possess the ability to self-renew and differentiate into committed spermatogonial progenitor cells (SPCs) ( single (A s ), A paired (A pr ) and A aligned (A al ) spermatogonia and can be distinguished by several genes, including Ngn3 , Sox3 , Gfr1 and Plzf ( Gfr1 + cells (mainly A s , A pr , and some A al ) are stem cells that can transform into Ngn3/Sox3 + (mainly A al and some A pr ) committed SPCs

The nicotine in cigarettes is so addictive that cold-turkey attempts to quit usually fail

37 , 37202 (IARC, Lyon, 1985)

Traumatic tattooing occurs when foreign substances or particles get buried in several layers of skin as a result of trauma

SCOGS (Select Committee on GRAS Substances)

C646, as a competitive inhibitor of p300, can antagonize acetyl coenzyme a, which is the substrate of acetylation of p300 and exerts anti-tumor activity in many cancer cell lines such as prostate cancer and leukemia
