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Our body is exposed to countless chemicals, bacteria, and other toxins daily

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Moreover, circadian rhythm disorders induced by darklight cycle disruption significantly disrupted bone metabolism and destroyed the structure of subchondral bone in the hindlimbs of OA rats, as evidenced by decreased BMD, percent bone volume with respect to total bone volume, and trabecular number, an increased ratio of the nuclear factor B ligand (Rankl)/osteoprotegerin and activation of the mononuclear/phagocyte system in the bone marrow [142]

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