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The industry invests approximately US$5 billion annually in R&D focused on validating 95% harm-reduction claims

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23, 2011, [21] See generally Department of State, The Global Illicit Trade in Tobacco: A Threat to National Security, December 2015, [22] Ulrik Boesen, Cigarette Taxes and Cigarette Smuggling by State, 2018, Tax Foundation, Nov

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