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What to actually do about it The strongest evidence for what changes the body composition equation comes from a randomized, head-to-head, placebo-controlled trial published by Lundgren and colleagues in NEJM in 2021

If pain is consistent, try different spots within the thigh zone

Research suggests that many people regain weight after discontinuing GLP-1 medications, which means you may need to continue treatment indefinitely to maintain weight loss

But GLP-1 isn't a drug

The slight difference in results is not clinically significant, and individual results vary based on adherence to diet and exercise recommendations

We believe that medications that help people live better should be affordable and accessible