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Gastroenterology 85 , 11201130 (1983)

Weight loss specialists generally avoid this combination due to safety risks and lack of clinical trial data supporting its use

Clinical data indicates average weight loss of 3 to 8 pounds during the first four weeks, with variation based on starting weight and individual metabolism

But because obesity drives many of the major diseases of aging, including heart disease, cancer, dementia, arthritis and diabetes, the US Centers for Medicare and Medicaid Services says it makes sense to pilot a test to see whether the medications might ultimately save the program money and improve health outcomes

The gastrointestinal side effects can potentially lead to dehydration, which may increase the risk of acute kidney injury in susceptible individuals

While it can offer significant benefits for controlling diabetes, its also associated with a range of side effects that patients should be aware of