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Patients were randomized to follow a therapeutic cycle for a total period of eight years: citicoline (1,000 mg/day, by intramuscular injection) or placebo (-blockers alone) for a two-month period followed by a four-month washout period (87)

To face these challenges, comprehensive preventive activities at the population level are needed, especially those concerning primary prophylaxis, which should be concentrated on selection of high-risk patients, adequate widespread health education, and optimum treatment (including non-pharmacological interventions), to avoid or delay development of ischaemic heart disease, stroke, or peripheral artery disease

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Wide-field images capture overall distribution, while close-up dermoscopic photos document individual lesion morphology