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10.1016/j.reprotox.2016.06.009 43 NguyenT.LiG

Putting p53 in context

Acknowledgements Authors would like to thank Professor Srimonti Sarkar, Bose Institute, Kolkata and Stuti Chatterjee for the critical reading and constructive criticism during the manuscript preparation

p53 also promotes autophagy by upregulating negative regulators of the AKT/mTOR pathway, such as PTEN and sestrins [81]

Additionally, statins are degradation inducers of conformational or misfolded mutp53, which induce CHIP-mediated mutp53 degradation by inhibiting the interaction of mutp53 with DNAJA1, but have little effect on wtp53 and DNA contact mutants [51]

Hinata N, Shirakawa T, Zhang Z, Matsumoto A, Fujisawa M, Okada H, et al