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[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care

41 Furthermore, overexpression of a constitutively active form of AMPK has been reported to increase lifespan to a greater extent than aak-2 upregulation

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27,28 More recently, the docosanoids produced from C22-PUFAs, including the 6 fatty acid AdA and the 3 fatty acids DPAn-3 and DHA, have been investigated