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10.1128/IAI.00709-10 75 FishD

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The largest part of patients carry small COL5A1 pathogenic variants and the majority of these are null alleles (nonsense, frameshift, out-of-frame splice) leading to functional haploinsufficiency

This makes them especially vulnerable to thirdhand smoke, the toxic chemical residue from tobacco smoke that lingers on surfaces for years after someone smokes or vapes