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Description
It has been shown that the expression of SIRT1 was decreased when exposed to CS both in vivo and in vitro [43,44,45]

Delivery of wtp53 into cancer cells via adenovirus is a direct strategy that rescues p53 activity in cancer
Cheung EC, Athineos D, Lee P, Ridgway RA, Lambie W, Nixon C, et al

Robot or human
In mouse models of pancreatic and lung cancer, loss of p53 regulates the tumor microenvironment, which promotes the accumulation of suppressor Treg cells as well as impairs Th1 and CD8 + T cell responses [62]

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