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It has been shown that the expression of SIRT1 was decreased when exposed to CS both in vivo and in vitro [43,44,45]

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Delivery of wtp53 into cancer cells via adenovirus is a direct strategy that rescues p53 activity in cancer

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Cheung EC, Athineos D, Lee P, Ridgway RA, Lambie W, Nixon C, et al

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In mouse models of pancreatic and lung cancer, loss of p53 regulates the tumor microenvironment, which promotes the accumulation of suppressor Treg cells as well as impairs Th1 and CD8 + T cell responses [62]

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