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Though nicotine has been associated with negative health implications, the long-term effects of ENDS containing nicotine consumption are still presently unknown [25]

Simulation modeling with sensitivity analyses that examine all the states and transition pathways in the state transition model (Figure 3) show that the gateway effect would have to be implausibly large to increase the net public health harm (20

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Ireland has set a target to be tobacco-free by 2025 - meaning a smoking prevalence rate of less than 5%

"Sensational media coverage and targeted efforts by those opposed to tobacco harm reduction are distorting the facts and keeping many of the world's one billion smokers from making better choices for their health." The Global State of Smoking Poll surveyed the smoking habits and perceptions of more than 54,000 current and former tobacco and tobacco harm reduction users

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