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Description
Obesity (Silver Spring) 2022;30(11):21112121
Gastrointestinal effects and referred pain: The pronounced gastrointestinal side effects of GLP-1 therapyparticularly nausea, constipation, and abdominal distensioncan occasionally manifest as referred pain to the back
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Discussion Treatment of T2D patients with GLP-1 analogues results in various beneficial effects, including improvement in -cell function and glucose homeostasis 7

Patients with pre-existing cardiac arrhythmias or significant cardiovascular disease should be monitored appropriately when initiating GLP-1 therapy, though these conditions are not absolute contraindications

LIMITATIONS OF CURRENT EVIDENCE AND GAPS IN KNOWLEDGE Despite the increasing information on gut microbiota as a modulator of antidiabetic drug effects, there are still systematic and conceptual gaps in the data available
