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Leafy green vegetables, for example, contain high levels of vitamin K

For those impurities that are present at acceptable levels, an in silico risk assessment can identify immunogenic risk at an early stage in the development process, enabling the removal of higher risk impurities while also indicating additional in vitro assays (HLA binding and T cell assay) that would be most useful in further evaluating immunogenicity

These are typically more pronounced during the initiation phase and may subside over time
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On the other hand, fluoxetine is a medication that has been around for decades

This distinction is detailed throughout the report
