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One theory is THC, or tetrahydrocannabinol, the chemical in marijuana that causes the feeling of being high. Because it is only legal for recreational purposes in 11 states, users in other states rely on the black market for it

Signage requirements are found in Section 20 of Chapter 82 and state: (a) No Smoking signs or the international No Smoking symbol, consisting of a pictorial representation of a burning cigarette enclosed in a red circle with a red bar across it, shall be clearly and conspicuously posted in each public place and place of employment where smoking is prohibited by this Act by the owner, operator, manager, or other person in control of that place

Even medical users can develop tolerance or dependency over time

Although the FTC and court antitrust analyses have defined the market as the entire U.S., geographic submarkets (eg, states, regions) may also be relevant

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The Swedish government requested assistance from a pharmaceutical company, and in 1967 Ove Ferno, a researcher at Pharmacia (now merged with Pfizer), developed a nicotine replacement gum to placate the symptoms of withdrawal