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Taken together, the homeostasis of MDM2p53 axis can promote hepatocyte proliferation, xenobiotic detoxification, and OXPHOS-mediated energy metabolism

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Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression

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Additionally, a calcitriol-elicited downregulation of the anti-apoptotic BCL2 and BCLXL and overexpression of the pro-apoptotic BAX, BAK , and BAD genes have also been described [147]

Figure 2 First, p53 can directly affect oxidative stress or be affected by oxidative stress