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Medicinal Research Reviews 32 (2012) 637-658

However, in disease states, this interaction may turn maladaptive, promoting inflammation and neurodegeneration

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Safety concerns also arise from the broad roles of epigenetic regulators in normal cells, exemplified by the narrow therapeutic window of HDAC or histone lysine methyltransferase (DOT1L) inhibitors

Chronic p53 activity leads to skeletal muscle atrophy and muscle stem cell perturbation