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This article is part of the special issue on Impact of lifestyle and behavioral risk factors on endothelial function and vascular biology in Pflgers ArchivEuropean Journal of Physiology Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Yes, smoking significantly increases the risk of heart attack, atherosclerosis, hypertension, and peripheral artery disease