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Clinically, GLP-1RAs could lead to an improvement in cognitive function, which is often found to be impaired across several conditions such as psychosis 240 and mood disorders 241 , eventually leading to an overall benefit as observed in some of the included studies (Tables 4 and 5)

( C ) Expression level of INS (red), GCG (green), and PCSK1 (purple) projected on the UMAP generated from human islet cells using DROP-Seq and DART-Seq, respectively

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Semaglutide's adverse effects are predominantly gastrointestinal, particularly during dose escalation