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Up to sixty percent of those with bipolar disorder have abused substances at one point in their lives

Thus, it has been hypothesized that smoking is an effort to self-medicate in people with severe mental disorders (30), including BD, in terms of alleviating cognitive deficits (31), depression (32, 33) and reducing extrapyramidal symptoms associated with antipsychotic treatment

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The findings from our trial can help the FDA implement required pictorial warnings on cigarette packs in the U.S. The authors used four pictorial warnings that contained text required by the Tobacco Control Act and pictures illustrating the harms of smoking, which were selected from the FDAs originally proposed set of images