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The global market for this type of product is small, but growing, and being sold in over sixty-one markets across Europe, North and South America, Asia and online

Regarding spilanthol ( 6 ) (45, 90, and 180 M), the most widely recognized active compound, it dose-dependently inhibited the mRNA expression and protein production of LPS-induced iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2) in RAW 264.7 cells

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