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287 The currently developed JHU-083 is a prodrug of 6-Diazo-5-oxo-L-norLeu (L-DON) generation glutaminase inhibitor that selectively activates L-DON in the TME

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These abnormalities include hypoplasia of the ipsilateral breast, areola, nipple and arm, ipsilateral arm shortening, lumbar spina bifida, thoracic scoliosis and pectus carinatum, as well as enlargement of the ipsilateral foot