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[4] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases

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Benowitz, who was not involved in the study, said the new findings are an important contribution to existing research but arent really ready for translation to clinical practice or regulatory standards. Benowitz, a professor at the Center for Tobacco Control and Research and Education at the University of California, San Francisco, said because the study was done on cells in a lab, it doesnt accurately assess the effect these substances have on cell and organ function in the body

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World J Gastroenterol 20:14787 Mujeeb F, Bajpai P, Pathak N (2014) Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos