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Dopamine release is critical to reinforcing effects of nicotine, as it signals a pleasurable experience

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Clonal haematopoiesis was also associated with a 36% increase in lung cancer risk among the UK Biobank participants after adjusting for major risk factors, including pack-years of smoking, age at sequencing, family history of lung cancer and lung cancer PRS 192

And this despite the fact that smoking still represents the greatest threat to human health, directly causing 93,000 more deaths than alcohol, drugs, road accidents, AIDS, homicide and suicide combined

Other rank orders received minimal support from the data (Supplementary Table 1)