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Description
4-hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
( 5 ) There, it binds to nicotinic acetylcholine receptors, triggering the release of several neurotransmitters, including dopamine (feelings of reward and pleasure), norepinephrine (focus and alertness), acetylcholine (attention and memory), serotonin (mood and sleep), and beta-endorphone (pain reduction and mood elevation)

If youre able, quit smoking slowly over several weeks rather than abruptly
doi:10.2105/AJPH.2014.301991
LBS Nastty Released April 1, 2025

PMID 14512270
