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WIN also showed a significant increase in the percentage of cells in the G1 phase and a decrease in the percentage of cells in the S phase suggesting that WIN cause cell cycle arrest in prostate cancer cells, although a previous study reported that there was no significant difference in the distribution of PC3 cells treated with endocannabinoids across the cell cycle phases compared with the control non-treated group of PC3 cells (Singh et al

Reynolds sued the company for making gray-market cigarette sales