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Thereby, thiocyanate may be responsible for the goitrogenic effect of cigarette smoking seen at least in iodine deficient areas.[] Variations in iodine intake might also modulate the response to smoking, the predominant action of smoking being antithyroid when iodine intake is low and immunogenic when it is adequate.[] Whether thiocyanate affects the peripheral action of T3 or T4 is currently not known
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