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Pharmacological guidance recommends discontinuing therapy after at least 5 half-lives to minimize fetal exposure

Zhang Y, Zhang J, Wang Q, et al

The mechanism of action is attributed to the GIP/GLP-1 receptor co-agonism being enhanced by glucagon receptor activation and augmentation of energy intake, substrate utilisation and energy expenditure [60]

Dual benefits and risks: tirzepatides impact on pancreatic function

Intranasal insulin treatment also prevented the decline in cerebral glucose metabolism [160]

Combination therapy with canagliflozin plus liraglutide exerts additive effect on weight loss, but not on HbA1c, in patients with type 2 diabetes