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Kasuga et al., in 2005, performed a replication study where the tentative association between HLA-B7 and COPD described by Kauffmann was analyzed using a casecontrol design in smokers

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We used these to trace sex differences with and without smoking-attributable mortality in period life expectancy between ages 50 and 85

The presence of carbon dioxide alongside carbon monoxide further disrupts normal respiratory drive and oxygen exchange processes, exacerbating respiratory dysfunction

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