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In 1874 the Duke tobacco manufacturing moved from the homestead into Durham to be near the railroad

Pretty complicated stuff, right

The participants were first classified into three groups based on their smoking status, namely "never-smokers," "ex-smokers," and "active smokers," using self-reported questionnaires

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Additional study authors include Christopher Anderson and Yue-Lin Zhuang at UC San Diego Moores Cancer Center, Hai-Yen Sung at the Institute of Health and Aging at UC San Francisco, and Anthony Gamst at the Computational and Applied Statistics Laboratory in the San Diego Supercomputer Center and Department of Mathematics at UC San Diego

It has melded seamlessly with the Virginias, which themselves have undergone a remarkable metamorphosis