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Future research should also address whether CSE-induced downregulation of glycolytic flux is caused by disruption of the transcriptional activity of HIF-1 or by a recently reported mechanism by which HIF-1 is involved in the cytoplasmic formation of a metabolic complex involving several glycolytic enzymes [63]

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The lack of significant statistical difference between smokers with and without acne regarding the cumulative smoking dose (considering that the calculation does not take numerous variables into account such as type of cigarettes smoked, manner of smoking, passive smoking, possible suspension periods, inaccurate number of cigarettes referred, possible variations in the number of cigarette smoked) could suggest that the clinical expression of acne in these patients could be related to genetic predisposition