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The pleasure of smoking is just the relief of the discomfort caused by the previous cigarette. Allen Carr According to a 2010 review in Neuropharmacology, nicotine alters brain circuitry involved in emotion, impulse control, and cognition, particularly in the prefrontal cortex and hippocampus, which are crucial for memory and decision-making

It is primarily synthesized in the liver and upon its release in the circulation, it becomes enzymatically modified affecting its fibrin-crosslinking and plasmin binding abilities [125]

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Tindle HA, Shiffman S, Hartman AM, and Bost JE