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Downregulation in smokers compared to never smokers was also observed by Mascaux et al

Metabolic interrogation as a tool to optimize chemotherapeutic regimens

Randomized control trials provide growing evidence that e-cigarettes with nicotine can increase quitting rates when compared to nicotine replacement therapies
The complexity of p53-mediated metabolic regulation in tumor suppression
p53 is thought to also be involved in the regulation of the death receptor apoptotic pathway by upregulating target genes, such as those for FAS [11, 12], Death Receptor 5 (DR5) [13], TNF receptor-associated protein 4 (TRAF4) [14] and SUSD6 (DRAGO
J Cell Biol 218(2):632643