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Physiological dependence : Evidence of tolerance and withdrawal symptoms strongly suggests alcohol dependence (F10.2x) rather than abuse (F10.1x)

In infants, it causes sudden death

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However, in a study comparing the safety of 4 mg nicotine lozenges and 4 mg nicotine gums, it was found that the lozenges were similarly well tolerated as the gums and had no worsening effect on the patients with cardiovascular diseases (54)

The theme focuses on the on the curing style for the Connecticut Broadleaf wrapper usedas the entire tobacco plant is cut at the base, allowing the leaves to extract nutrients from the tobacco stalk as they cure