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More than 5 million are users and ex-users and more than 600 000 are non-smokers exposed to second-hand smoke according to the World

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When the wind blows to one end, smoke will come out

Assessing the lung cancer risk reduction potential of cMRTPs is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon cessation and a fortiori upon switching to a cMRTP

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