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On the other hand the users of tobacco are scarcely less vehement in holding that no harmful effects follow, but ascribing all kinds of virtue as resulting from its use

This is a long-lasting accumulated effect that usually appears when someone has, in their lifetime, consumed more than 7 kilogram of ethanol per kilogram of body weight in men (equivalent to 60 drinks per month, or two per day), and 5 kilogram of ethanol per kilogram of body weight in women (equivalent to 43 drinks per month, roughly 1.5 per day) (12)

Journal of Umm Al-Qura University for Applied Sciences

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Nicotine patches giving off a steady, low amount of nicotine are preferred to nicotine gums which create higher fluctuation in nicotine levels