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Methods SOUL is a multicenter, double-blind, placebo-controlled randomized controlled trial (RCT) evaluating the reduction in MACE associated with oral semaglutide versus placebo in patients with type 2 diabetes (T2D) and cardiovascular (CV) disease

Also known as GLP-1 medications, these popular drugs were initially approved to treat type 2 diabetes, but doctors quickly discovered that they also facilitated significant weight loss thus, the birth of the weight-loss drug craze.