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Achieving this can be challenging and great care has to be given when choosing exposure dose ranges, which can be based on (i) animal to human exposure conversion factors for in vivo studies [82] and (ii) human data for in vitro studies [83, 84]

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A three-dimensional plot is then constructed, with cluster membership color-coded to visualize the separation between clusters (see Figure 9)

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Available data are contradictory when assessing the risk of perianal disease, since it was included in the definition of the fistulizing CD pattern in the initial Vienna phenotypic classification of CD[28], but not in the Montreal adaptation[29]