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6.1.3 Chronopharmacokinetics of Nicotine During sleep, hepatic blood flow declines and nicotine clearance falls correspondingly

[27] Pesticide [edit] Nicotine has been used as an insecticide since at least 1690, in the form of tobacco extracts or as pure nicotine sulfate [14] [28] [29] (although other components of tobacco also seem to have pesticide effects)

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