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This enhancement is accompanied by upregulation of classic embryonic stem cell transcription factors such as Sox2, Oct4, and Nanog, likely mediated through the induction of c-Kit ligand/Stem Cell factor [54]

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A Report of the Surgeon General., U.S
Smoking induces the production and activity of MMPs responsible for extracellular matrix degradation, and alters the production of their biological inhibitors, tissue inhibitors of MMPs (TIMPs) released by alveolar macrophages

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