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Similar content being viewed by others Introduction Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy, with over 657,000 newly diagnosed cases and 330,000 deaths per year worldwide 1

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4 In summary, the available results of late generation sequencing studies as well as the extensive data bases on TP53 and KRAS mutations are completely consistent with the induction of multiple mutations in critical growth control genes by metabolically activated carcinogens