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But, it does say that cosmetic products must be safe for their intended use
10.1111/jcmm.17309 115 WangT.YuM.LiH.QinS.RenW.MaY.et al (2023a)
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Furthermore, compared to oral administration, rectal administration can avoid degradation in the digestive system, increase local rectal drug concentrations, and reduce systemic toxic side effects [29,30,31,32,33,34]

(2012) support that E2 regulates the expression of Bcl-2, an anti-apoptotic protein, and survivin, which inhibits caspase activation, by the suppression of different miRNAs, including miR-16, miR-143 and miR-203

Free Radic Biol Med 19: 227-250